TO: MEMBERS OF THE CYSTIC FIBROSIS GENETIC ANALYSIS CONSORTIUM

Beaudet, Baylor, USA Kant, U. Penn, USA

Boué, Bologne, France Kitzis, CHU-Paris, France

Bowcock, Stanford, USA Klinger, Integ Genet, USA

Cao, U Cagliari, Italy Lucotte, College de France

Cassiman, U Leuven, Belgium Malcolm, ICH-London, England

Claustres, Montpellier, France Malik, Basler-Basel, Switzerland

Collins, U Michigan, USA Mao, Collab Res, USA

Cutting, Johs Hopkins, USA McIntosh, WGH-Edinburgh, Scotland

Dallapiccola, Roma, USA Morgan, McGill, Canada

Dean, NCI Frederick, USA Naylor, UT San Antonio, USA

Edwards, Oxford, England Olek, U Bonn, West Germany

Elles, St Mary's-Manchester, England Orr, U Minnesota, USA

Erlich, Cetus, USA Pignatti, U Verona, Italy

Estivill, Barcellona, Spain Ramsay, SAMIR, South Africa

Ferec, Brest, France Richards, GeneScreen, USA

Ferrari, Milano, Italy Romeo, Gaslini-Genoa, Italy

Godet, Villeurbanna, France Rozen, Montreal Children, Canada

Goossens, Creteil, France Scheffer, U Gottingen, The Netherlands

Graham, Belfast, N Ireland Schmidtke, IHG, Berlin

Gruenert, UCSF, USA Schwartz, U Copenhagen, Denmark

Halley, Rotterdam, The Netherlands Super, Royal Manchester, England

Harris, Guy's-London, England Tsui, Toronto, Canada

Highsmith, NC Mem Hosp, USA Tümmler, Hannova, West Germany

Horst, Münster, West Germany Williamson, St Mary's-London, England

Jaume-Roig, Son Dureta, Spain

Kalaydjieva, Sofia, Bulgaria

FROM: LAP-CHEE TSUI

TOTAL NUMBER OF PAGES: 5

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NEWSLETTER #3, January 19, 1990

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1. A new mutation was reported by Gary Cutting. It is a G->A switch at nucleotide position 1784, which results in a Gly->Asp substitution (see letter received Jan 8, 1990).

2. It has not been easy to send a 25-page document to 50 different places, even with a fancy FAX machine, not to mention the ones with machine or line problems. In addition, some transmission did not find their way to members' hands. In order to avoid the latter problem, letters are now sent with the investigators' names on the cover sheet. Please let me know the best way to identify yourself, if the current one is unsatisfactory. I will continue to do the mailing at night to avoid heavy traffic. It will also help if we reduce the number of pages to be broadcasted in the future. So, please write short notes instead of long letters. Also, pictures transmit poorly- please use schematic diagrams if possible.

3. Please do not encourage your friend(s) to submit their names to the consortium in order to receive newsletters only. I think we all understand that we are a working group and we expect contribution from each member.

Sincerely,